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Notch signaling is impaired in the eIF5A ΔPANC mutant pancreas. Representative images of E11.5 (A) Ptf1a-cre and (B) eIF5A ΔPANC pancreata stained for E-cadherin (green), <t>Hes1</t> (red) and nuclei (DAPI, blue). These tissue sections also show expression of the tdTomato reporter, which is visualized in the green channel. (C) Quantification of the Hes1-expressing cells within the pancreas showed no significant difference between Ptf1a-cre controls and eIF5A ΔPANC mutants. Representative images of E14.5 (D) Ptf1a-cre and (E) eIF5A ΔPANC pancreata stained for E-cadherin (green), Hes1 (red) and nuclei (DAPI, blue). (F) Quantification of the Hes1-expressing cells within the pancreas showed a significant decrease in eIF5A ΔPANC mutants. Gene expression analysis of (G) Hes1 , (H) Notch1 , (I) Ngn3 , and (J) Eif5a in E14.5 pancreata from Ptf1a-cre controls and eIF5A ΔPANC mutants. Data are presented as mean +/− SEM; n = 4–5/group; ∗, p < 0.05; ∗∗, p < 0.01; ∗∗∗, p < 0.001.
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Notch signaling is impaired in the eIF5A ΔPANC mutant pancreas. Representative images of E11.5 (A) Ptf1a-cre and (B) eIF5A ΔPANC pancreata stained for E-cadherin (green), <t>Hes1</t> (red) and nuclei (DAPI, blue). These tissue sections also show expression of the tdTomato reporter, which is visualized in the green channel. (C) Quantification of the Hes1-expressing cells within the pancreas showed no significant difference between Ptf1a-cre controls and eIF5A ΔPANC mutants. Representative images of E14.5 (D) Ptf1a-cre and (E) eIF5A ΔPANC pancreata stained for E-cadherin (green), Hes1 (red) and nuclei (DAPI, blue). (F) Quantification of the Hes1-expressing cells within the pancreas showed a significant decrease in eIF5A ΔPANC mutants. Gene expression analysis of (G) Hes1 , (H) Notch1 , (I) Ngn3 , and (J) Eif5a in E14.5 pancreata from Ptf1a-cre controls and eIF5A ΔPANC mutants. Data are presented as mean +/− SEM; n = 4–5/group; ∗, p < 0.05; ∗∗, p < 0.01; ∗∗∗, p < 0.001.
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Notch signaling is impaired in the eIF5A ΔPANC mutant pancreas. Representative images of E11.5 (A) Ptf1a-cre and (B) eIF5A ΔPANC pancreata stained for E-cadherin (green), Hes1 (red) and nuclei (DAPI, blue). These tissue sections also show expression of the tdTomato reporter, which is visualized in the green channel. (C) Quantification of the Hes1-expressing cells within the pancreas showed no significant difference between Ptf1a-cre controls and eIF5A ΔPANC mutants. Representative images of E14.5 (D) Ptf1a-cre and (E) eIF5A ΔPANC pancreata stained for E-cadherin (green), Hes1 (red) and nuclei (DAPI, blue). (F) Quantification of the Hes1-expressing cells within the pancreas showed a significant decrease in eIF5A ΔPANC mutants. Gene expression analysis of (G) Hes1 , (H) Notch1 , (I) Ngn3 , and (J) Eif5a in E14.5 pancreata from Ptf1a-cre controls and eIF5A ΔPANC mutants. Data are presented as mean +/− SEM; n = 4–5/group; ∗, p < 0.05; ∗∗, p < 0.01; ∗∗∗, p < 0.001.

Journal: Molecular Metabolism

Article Title: Translating the blueprint of cell fate: eIF5A-mediated translation regulates cellular identity in the pancreas

doi: 10.1016/j.molmet.2026.102362

Figure Lengend Snippet: Notch signaling is impaired in the eIF5A ΔPANC mutant pancreas. Representative images of E11.5 (A) Ptf1a-cre and (B) eIF5A ΔPANC pancreata stained for E-cadherin (green), Hes1 (red) and nuclei (DAPI, blue). These tissue sections also show expression of the tdTomato reporter, which is visualized in the green channel. (C) Quantification of the Hes1-expressing cells within the pancreas showed no significant difference between Ptf1a-cre controls and eIF5A ΔPANC mutants. Representative images of E14.5 (D) Ptf1a-cre and (E) eIF5A ΔPANC pancreata stained for E-cadherin (green), Hes1 (red) and nuclei (DAPI, blue). (F) Quantification of the Hes1-expressing cells within the pancreas showed a significant decrease in eIF5A ΔPANC mutants. Gene expression analysis of (G) Hes1 , (H) Notch1 , (I) Ngn3 , and (J) Eif5a in E14.5 pancreata from Ptf1a-cre controls and eIF5A ΔPANC mutants. Data are presented as mean +/− SEM; n = 4–5/group; ∗, p < 0.05; ∗∗, p < 0.01; ∗∗∗, p < 0.001.

Article Snippet: Real-time PCR was performed using TaqMan Gene Expression Master Mix (Applied Biosystems) and TaqMan probes for Notch1 (catalog #: Mm00627185_m1), Hes1 (catalog #: Mm00468601_m1), Ngn3 (catalog #: Mm00437606_s1), Eif5a (catalog #: Mm00839121_gH), Ins1 (catalog # Mm01259683_g1), Gcg (catalog # Mm00801714_m1), Sst (catalog # Mm00436671_m1), and Luciferase (catalog #: Mr03987587_mr).

Techniques: Mutagenesis, Staining, Expressing, Gene Expression